N-(tert-Butoxycarbonyl)-4-chloro-L-phenylalanine → N-[4-chloro-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-3-mercapto-D-valine, methyl ester

HRID 1586889노트

반응식

HRID 1586889 반응식
[C:1]([NH:8][C@H:9]([C:18]([OH:20])=O)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl.[CH3:22][O:23][C:24](=[O:31])[C@@H:25]([C:27]([SH:30])([CH3:29])[CH3:28])[NH2:26]>>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([CH2:10][C@@H:9]([C:18]([NH:26][C@@H:25]([C:24]([O:23][CH3:22])=[O:31])[C:27]([SH:30])([CH3:29])[CH3:28])=[O:20])[NH:8][C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])=[CH:16][CH:15]=1

참가 물질

3

반응물 2

HCID 2734499N-(tert-Butoxycarbonyl)-4-chloro-L-phenylalanineHCID 12278508Methyl 3-mercapto-D-valinate hydrochloride

생성물 1

HCID 131717962N-[4-chloro-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-3-mercapto-D-valine, methyl ester

실험 절차

The title compound was synthesized by coupling Nα -Boc-(p-chloro) phenylalanine (4.96 g, 16.5 mmol) to 3.6 g (18.2 mmol) of D-penicillamine methylester hydrochloride using the procedure described above in Example 19. The title compound was obtained as a white solid (6.2 g, 84.5%).

후처리

  1. customThe title compound was synthesized

출처 및 근거

ORD 기록
ord-11223222274643f181ef5255eb79e248
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216124

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