Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(tert-Butoxycarbonyl)-4-chloro-L-phenylalanine → N-[4-chloro-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-3-mercapto-D-valine, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(tert-Butoxycarbonyl)-4-chloro-L-phenylalanine | HCID 2734499 | — |
| 반응물 | Methyl 3-mercapto-D-valinate hydrochloride | HCID 12278508 | — |
| 생성물 | N-[4-chloro-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-3-mercapto-D-valine, methyl ester | HCID 131717962 | — |
반응 단계
The title compound was synthesized by coupling Nα -Boc-(p-chloro) phenylalanine (4.96 g, 16.5 mmol) to 3.6 g (18.2 mmol) of D-penicillamine methylester hydrochloride using the procedure described above in Example 19. The title compound was obtained as a white solid (6.2 g, 84.5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05216124 |
| 출처 데이터셋 | uspto-grants-1993_06 |
| ORD ID | ord-11223222274643f181ef5255eb79e248 |
| 출처 메모 | uspto-grants-1993_06 |