2-Methyl-5-hydroxypyridine → HCID 135492986, compound

HRID 1586923Notes

Reaction equation

HRID 1586923 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Pb](=O)=O>C1(C)C=CC=CC=1>[OH:8][C:5]1[C:6]([C:6]2[C:5]([OH:8])=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=2)=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 142752-Methyl-5-hydroxypyridineHCID 14793Lead dioxide

Product 1

HCID 135492986HCID 135492986, compoundYield 9.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

6-Methyl-3-hydroxypyridine (23.9 g, 0.219 moles), lead dioxide (98.3 g, 0.411 moles) and toluene (1 liter) were combined and refluxed for five hours. The hot solution was filtered and evaporated to dryness. The residue was refluxed with hexane and filtered while hot. The solution was evaporated to dryness giving the product as a yellow powder.

Workup

  1. temperaturerefluxed for five hours
  2. filtrationThe hot solution was filtered
  3. customevaporated to dryness
  4. temperatureThe residue was refluxed with hexane
  5. filtrationfiltered while hot
  6. customThe solution was evaporated to dryness

Sources & evidence

ORD record
ord-3279eea3e567486b942b6f8529b4ce90
Source dataset
uspto-grants-1993_06
Patent number
US05216134

Reaction notes

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