HRID1586936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID4393691

Di-tert-butyl iminodiacetate

C12H23NO4

HCID19760129

4,4′-Bis(chloromethyl)-2,2′-bipyrimidine

C10H8Cl2N4

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)Cc1ccnc(-c2nccc(CN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)n2)n1

HCID19760126

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

4,4'-Bis(chloromethyl)-2,2'-bipyrimidine (18.0 mg, 0.0793 mmoles), di-t-butyl iminodiacetate (76.3 mg, 0.31 mmoles), sodium carbonate (210 mg) and acetonitrile (3 ml) were refluxed overnight. The mixture was filtered, the solvent was evaporated and the product was purified by flash chromatography (silica, 0-5% methanol/chloroform).

WORKUP

后处理

filtrationThe mixture was filtered
customthe solvent was evaporated
customthe product was purified by flash chromatography (silica, 0-5% methanol/chloroform)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ae7fa321c324cd4a1d2146bfa9d575b
来源数据集: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05216134
来源说明: uspto-grants-1993_06

反应 SMILES

Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[N:14]=[C:13]([CH2:15]Cl)[CH:12]=[CH:11][N:10]=2)[N:4]=1.[NH:17]([CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].[C:34](=[O:37])([O-:36])[O-].[Na+].[Na+]>C(#N)C>[C:30]([O:29][C:27]([CH2:26][N:17]([CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[N:14]=[C:13]([CH2:15][N:17]([CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:23])[CH3:24])=[O:20])[CH2:26][C:34]([O:36][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:37])[CH:12]=[CH:11][N:10]=2)[N:4]=1)[CH2:18][C:19]([O:21][C:22]([CH3:24])([CH3:25])[CH3:23])=[O:20])=[O:28])([CH3:33])([CH3:32])[CH3:31]