HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4,4'-Bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | DI-T-Butyl iminodiacetate | HCID 4393691 | — |
| Reactant | 4,4'-Bis(chloromethyl)-2,2'-bipyrimidine | HCID 19760129 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4,4'-Bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyrimidine | HCID 19760126 | — |
Reaction Steps
4,4'-Bis(chloromethyl)-2,2'-bipyrimidine (18.0 mg, 0.0793 mmoles), di-t-butyl iminodiacetate (76.3 mg, 0.31 mmoles), sodium carbonate (210 mg) and acetonitrile (3 ml) were refluxed overnight. The mixture was filtered, the solvent was evaporated and the product was purified by flash chromatography (silica, 0-5% methanol/chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05216134 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-3ae7fa321c324cd4a1d2146bfa9d575b |
| Source note | uspto-grants-1993_06 |