N-Benzoyl-4-piperidone → (4-Aminopiperidin-1-yl)(phenyl)methanone

N-Benzoyl-4-piperidone (45.92 g, 226 mmol) was converted to the oxime by treatment with HONH2.HCl (237 mmol, 16.49 g) in 90 ml of methanol and 90.4 ml of 2.5N NaOH. After stirring overnight, the reaction was concentrated under reduced pressure and three times treated with toluene and reconcentrated to remove the last traces of water. The resulting oxime (57 g) was dissolved in 1L of methanol, treated with 226 ml of 1N HCl and 4 g of PtO2. The mixture was then hydrogenated in a Paar apparatus at 50 psi. After 16.75 h, the catalyst was filtered and the methanol was concentrated in vacuo. Water (100 ml) was then added to the aqueous phase that was then extracted with 7×700 ml of CH2Cl2. The aqueous phase was made basic with 2.5N NaOH and extracted with 5×100 ml of CH2Cl2. The pooled extracts were concentrated in vacuo affording 18.17 g (88.9 mmol, 39% overall yield) of 4-amino-1-benzoylpiperidine as a yellow oil.

1. concentrationthe reaction was concentrated under reduced pressure and three times
2. additiontreated with toluene
3. customto remove the last traces of water
4. dissolutionThe resulting oxime (57 g) was dissolved in 1L of methanol
5. additiontreated with 226 ml of 1N HCl and 4 g of PtO2
6. waitAfter 16.75 h
7. filtrationthe catalyst was filtered
8. concentrationthe methanol was concentrated in vacuo
9. additionWater (100 ml) was then added to the aqueous phase that
10. extractionwas then extracted with 7×700 ml of CH2Cl2
11. extractionextracted with 5×100 ml of CH2Cl2
12. concentrationThe pooled extracts were concentrated in vacuo

ORD record

ord-2e8597710f0d491e83aa1f891c487676

Source dataset

uspto-grants-1993_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05216165