Hydrochloric Acid → 2-Butyrylamino-4-trichloromethylpyridine

HRID 1587006Notes

Reaction equation

HRID 1587006 reaction equation
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].[NH2:7][C:8]1[CH:13]=[C:12]([C:14]([Cl:17])([Cl:16])[Cl:15])[CH:11]=[CH:10][N:9]=1.Cl>N1C=CC=CC=1>[C:1]([NH:7][C:8]1[CH:13]=[C:12]([C:14]([Cl:15])([Cl:17])[Cl:16])[CH:11]=[CH:10][N:9]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8855Butyryl chlorideHCID 137101174-(Trichloromethyl)pyridin-2-amine

Product 1

HCID 151568342-Butyrylamino-4-trichloromethylpyridineYield 90.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
25 °C

Procedure

7.3 ml (0.07 mol) of butyryl chloride were added to 10.6 g (0.05 mol) of 2-amino -4-trichloromethylpyridine and 70 ml of pyridine at 0° C. while cooling with ice. After stirring for three hours at 25° C., the reaction mixture was added to 5% strength hydrochloric acid and this mixture was extracted with ether. 12.7 g (90%) of the product wre obtained from the organic phase. Mp.: 88°-90° C., Active ingredient Example 1.003

Workup

  1. temperaturewhile cooling with ice
  2. extractionthis mixture was extracted with ether

Sources & evidence

ORD record
ord-02fe5379ecbf424d9af4962cf8bc1f12
Source dataset
uspto-grants-1993_06
Patent number
US05216171

Reaction notes

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