HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Methylaminocarbonylamino-4-trichloromethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 4-(Trichloromethyl)pyridin-2-amine | HCID 13710117 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Methylaminocarbonylamino-4-trichloromethylpyridine | HCID 15156835 | 82% |
Reaction Steps
17 ml (0.3 mol) of methyl isocyanate and 1 ml of triethylamine were added to 21.2 g (0.1 mol) of 2-amino-4-trichloromethylpyridine and 400 ml of toluene at 25° C. After 4 hours at 80° C., the resulting solid was isolated. 21.8 g (82%) of the desired product were obtained. Mp.: 192°-195° C.; Active Ingredient Example 2.001
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05216171 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-fb2afe49b8e34711b456079b31f2b18d |
| Source note | uspto-grants-1993_06 |