Triethylamine → 2-Methylaminocarbonylamino-4-trichloromethylpyridine

HRID 1587007Notes

Reaction equation

HRID 1587007 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].C(N(CC)CC)C.[NH2:12][C:13]1[CH:18]=[C:17]([C:19]([Cl:22])([Cl:21])[Cl:20])[CH:16]=[CH:15][N:14]=1>C1(C)C=CC=CC=1>[CH3:1][NH:2][C:3]([NH:12][C:13]1[CH:18]=[C:17]([C:19]([Cl:21])([Cl:20])[Cl:22])[CH:16]=[CH:15][N:14]=1)=[O:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 137101174-(Trichloromethyl)pyridin-2-amine

Product 1

HCID 151568352-Methylaminocarbonylamino-4-trichloromethylpyridineYield 82%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

17 ml (0.3 mol) of methyl isocyanate and 1 ml of triethylamine were added to 21.2 g (0.1 mol) of 2-amino-4-trichloromethylpyridine and 400 ml of toluene at 25° C. After 4 hours at 80° C., the resulting solid was isolated. 21.8 g (82%) of the desired product were obtained. Mp.: 192°-195° C.; Active Ingredient Example 2.001

Workup

  1. customthe resulting solid was isolated

Sources & evidence

ORD record
ord-fb2afe49b8e34711b456079b31f2b18d
Source dataset
uspto-grants-1993_06
Patent number
US05216171

Reaction notes

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