Sulfuric Acid → HCID 15027117, compound

HRID 1587259Notes

Reaction equation

HRID 1587259 reaction equation
[H-].[Li+].[Al+3].[H-].[H-].[H-].[Cl-].[Al+3].[Cl-].[Cl-].[F:11][C:12]([F:30])([F:29])[CH:13]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)=O.S(=O)(=O)(O)O>C(OCC)C>[F:11][C:12]([F:29])([F:30])[CH:13]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:14][CH2:15][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 6451240Aluminum(III) ChlorideHCID 15027116HCID 15027116, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 15027117HCID 15027117, compoundYield 100.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent3×

Procedure

To a mixture of 0.1 g of aluminum lithium hydride and 2.5 ml of dry diethyl ether, 0.275 g of aluminum chloride and 2.5 ml of dry diethyl ether were added under stirring. To the resultant mixture, a solution of 0.48 g of the above-prepared 4-(3-trifluoromethylheptanoyl)anisole in 2.5 ml of diethyl ether, followed by heat-refluxing for 30 minutes. After the reaction, 5 ml of 6N-sulfuric acid was added to the reaction mixture, followed by extraction with diethyl ether. The ether layer was dried with anhydrous sodium sulfate, followed by distilling-off of the solvent to obtain 0.46 g of crude 4-(3-trifluoromethylheptyl)anisole

Workup

  1. additionwere added
  2. temperatureby heat-refluxing for 30 minutes
  3. additionwas added to the reaction mixture
  4. extractionfollowed by extraction with diethyl ether
  5. dry with materialThe ether layer was dried with anhydrous sodium sulfate

Sources & evidence

ORD record
ord-3daeaa06fb224873a03a8faba134dbad
Source dataset
uspto-grants-1993_06
Patent number
US05217644

Reaction notes

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