Water → HCID 136331473, compound

HRID 1587281Notes

Reaction equation

HRID 1587281 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Cl[C:8]1[N:16]=[C:15]2[C:11]([NH:12][CH:13]=[N:14]2)=[CH:10][N:9]=1.[OH2:17]>COCCOCCOC.CN(C)C>[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[NH:9]1[C:10](=[O:17])[C:11]2[NH:12][CH:13]=[N:14][C:15]=2[N:16]=[C:8]1[NH2:1]

Participants

5

Reactant 2

HCID 962WaterHCID 19757664HCID 19757664, compound

Product 1

HCID 136331473HCID 136331473, compound

Reagents, catalysts & solvents 2

HCID 1146TrimethylamineSolventHCID 8150DiglymeSolvent

Procedure

The chloropurine pyrrolidone (1 mmol) from the previous paragraph is dissolved in diglyme (10 ml) and 25% aqueous trimethylamine (2 ml). The solution is stirred at rt for 5 h, water (10 ml) is added, and the mixture concentrated to 10 ml under reduced pressure. Acetic acid (2 ml) is added, and the mixture was evaporated under reduced pressure to an oil. The residue which contains trimethylammonium acetate is used directly for the next step.

Workup

  1. concentrationthe mixture concentrated to 10 ml under reduced pressure
  2. additionAcetic acid (2 ml) is added
  3. customthe mixture was evaporated under reduced pressure to an oil

Sources & evidence

ORD record
ord-267cabe13864485aa73d79c9bbc407b6
Source dataset
uspto-grants-1993_06
Patent number
US05217866

Reaction notes

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