1,4-Dioxane hydrochloride → 3-(2-Hydroxy-3-morpholinopropoxy)-5-phenylisoxazole hydrochloride

HRID 1587348Notes

Reaction equation

HRID 1587348 reaction equation
O[N:2]1[CH:6]([O:7][CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:5]=[C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:3]1.[ClH:23].[O:24]1CCOCC1>C(OCC)(=O)C>[ClH:23].[OH:24][CH:9]([CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[CH2:8][O:7][C:6]1[CH:5]=[C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:3][N:2]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 1317174032-Hydroxy-3-morpholinopropoxy-5-phenylisoxazole

Product 1

HCID 146520283-(2-Hydroxy-3-morpholinopropoxy)-5-phenylisoxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 5.00 g of 3-(2-hydroxy-3-morpholinopropoxy-5-phenylisoxazole dissolved in ethyl acetate (200 ml) was added a 4N HCl/dioxane solution (5.0 ml) and the mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to afford 5.21 g of the title compound with melting point 149°-150° C. as colorless powdery crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9a18c2478b394d7193fd731ff5478258
Source dataset
uspto-grants-1993_06
Patent number
US05217970

Reaction notes

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