2-Aminophenol → 2H-1,4-benzoxazin-3(4H)-one

HRID 1587353Notes

Reaction equation

HRID 1587353 reaction equation
Cl[CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13].[Cl-].C(C[NH3+])C1C=CC=CC=1.C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[O:4]=[C:3]1[NH:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[O:13][CH2:2]1

Participants

6

Reactant 4

HCID 58012-AminophenolHCID 6577Chloroacetyl chlorideHCID 516892Sodium BicarbonateHCID 2750517156-28-5

Product 1

HCID 727572H-1,4-benzoxazin-3(4H)-oneYield 32.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of chloroacetyl chloride (31.2 g) in chloroform (100 ml) was added dropwise to a mixture of 2-aminophenol (25 g), benzylmethylammonium chloride (52.4 g), sodium bicarbonate (77 g) and chloroform (500 ml) which was cooled in an ice-bath. The mixture was stirred for 1 hour and allowed to warm to ambient temperature. The mixture was heated to 55° C. for 5 hours and then stirred at ambient temperature for 16 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and an aqueous solution of potassium carbonate. The organic phase was washed with dilute aqueous hydrochloric acid and with water, dried (MgSO4) and evaporated. The residue was washed with a mixture of hexane and diethyl ether to leave 3-oxo-2,3-dihydro-4H-1,4-benzoxazine (11 g, 32%) m.p. 172°-173° C.

Workup

  1. temperaturewas cooled in an ice-bath
  2. temperatureThe mixture was heated to 55° C. for 5 hours
  3. stirringstirred at ambient temperature for 16 hours
  4. customThe mixture was evaporated
  5. customthe residue was partitioned between ethyl acetate
  6. washThe organic phase was washed with dilute aqueous hydrochloric acid and with water
  7. dry with materialdried (MgSO4)
  8. customevaporated
  9. washThe residue was washed with a mixture of hexane and diethyl ether

Sources & evidence

ORD record
ord-1657c5a9001f4a409b12d7048f1d9f2c
Source dataset
uspto-grants-1993_06
Patent number
US05217969

Reaction notes

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