Water → HCID 10248656, compound

HRID 1587402Notes

Reaction equation

HRID 1587402 reaction equation
[OH-].[Na+].C([NH:11][C:12](=[S:35])[NH:13][C:14]1[S:15][C:16]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=2)=[C:17]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)[N:18]=1)(=O)C1C=CC=CC=1.O>CO>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:18]=[C:14]([NH:13][C:12]([NH2:11])=[S:35])[S:15][C:16]=2[C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=2)=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 10367681HCID 10367681, compound

Product 1

HCID 10248656HCID 10248656, compoundYield 95.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of sodium hydroxide (0.36 g) in methanol (4.1 ml) was added to a solution of 2-(3-benzoylthioureido)-4,5-bis(4-methoxyphenyl)thiazole (4.3 g) and water (0.5 ml) in methanol (25 ml). The resulting mixture was stirred for 3 hours at 55°~60° C. The methanol was evaporated in vacuo and the residue was triturated with water. The precipitates were collected by filtration and dried to give 4,5-bis(4-methoxyphenyl)-2-thioureidothiazole (3.20 g).

Workup

  1. customThe methanol was evaporated in vacuo
  2. customthe residue was triturated with water
  3. filtrationThe precipitates were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-e983af8f82044837a82139a0d38a12f2
Source dataset
uspto-grants-1993_06
Patent number
US05217971

Reaction notes

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