Hydrogen Bromide → HCID 19758305, compound

Participants

Reaction Steps

1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one (70 mg) was dissolved in 10 ml of methylene chloride. The resulting solution was cooled to 0° C. and saturated with hydrogen bromide gas for 10 minutes. The reaction vessel was sealed and the reaction mixture was allowed to warm to room temperature over 0.5 hours. The vessel was vented and the solvent and excess hydrogen bromide gas were removed under reduced pressure to give 70 mg of the title compound.

Provenance & Evidence