Hydrogen Bromide → HCID 19758305, compound

HRID 1587482Notes

Reaction equation

HRID 1587482 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[N:13]1[CH:17]=[C:16]([CH2:18][N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[C:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[N:22][CH:21]([NH:36]C(OCC3C=CC=CC=3)=O)[C:20]2=[O:47])[N:15]=[CH:14]1)([O-:3])=[O:2].[BrH:48]>C(Cl)Cl>[BrH:48].[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[N:13]1[CH:17]=[C:16]([CH2:18][N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[C:23]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)=[N:22][CH:21]([NH2:36])[C:20]2=[O:47])[N:15]=[CH:14]1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 10009204HCID 10009204, compound

Product 1

HCID 19758305HCID 19758305, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one (70 mg) was dissolved in 10 ml of methylene chloride. The resulting solution was cooled to 0° C. and saturated with hydrogen bromide gas for 10 minutes. The reaction vessel was sealed and the reaction mixture was allowed to warm to room temperature over 0.5 hours. The vessel was vented and the solvent and excess hydrogen bromide gas were removed under reduced pressure to give 70 mg of the title compound.

Workup

  1. customThe reaction vessel was sealed
  2. customthe solvent and excess hydrogen bromide gas were removed under reduced pressure

Sources & evidence

ORD record
ord-2788c510f7e44f7897f5643f01df6eb5
Source dataset
uspto-grants-1993_06
Patent number
US05218115

Reaction notes

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