反应详情

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

1. custompartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. washThe organic layer was washed with water
3. customdried
4. concentrationconcentrated in vacuo
5. customThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]