HCID 19757885, compound → HCID 19757919, compound

HRID 1587534Notes

Reaction equation

HRID 1587534 reaction equation
C(OC([N:8]([S:60]([C:63]1[CH:68]=[CH:67][C:66]([CH3:69])=[CH:65][CH:64]=1)(=[O:62])=[O:61])[CH2:9][CH2:10][CH2:11][CH2:12][N:13]([C:52](=[O:59])[C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]([C:44](=[O:51])[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[CH2:22][CH2:23][CH2:24][CH2:25][N:26](C(OC(C)(C)C)=O)[S:27]([C:30]1[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=1)(=[O:29])=[O:28])=O)(C)(C)C>Cl>[CH3:36][C:33]1[CH:32]=[CH:31][C:30]([S:27]([NH:26][CH2:25][CH2:24][CH2:23][CH2:22][N:21]([C:44](=[O:51])[C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][N:13]([C:52](=[O:59])[C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=2)[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][S:60]([C:63]2[CH:64]=[CH:65][C:66]([CH3:69])=[CH:67][CH:68]=2)(=[O:62])=[O:61])(=[O:28])=[O:29])=[CH:35][CH:34]=1

Participants

3

Reactant 1

HCID 19757885HCID 19757885, compound

Product 1

HCID 19757919HCID 19757919, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dissolve 1,19-Bis(tert-butyloxycarbonyl)-1,19-bis[(4-methylphenyl)sulfonyl]-6,14-bis(benzoyl)-1,6,14,19-tetraazanonadecane (9.76 g, 10 mmol) in saturated methanolic hydrochloric acid (100 mL). Stir for several hours and evaporate the solvent in vacuo. Dissolve the residue in water and neutralize with saturated sodium hydrogen carbonate and extract with ethyl acetate. Dry (MgSO4) and evaporate the solvent in vacuo. Purify by silica gel chromatography to give the title compound.

Workup

  1. customevaporate the solvent in vacuo
  2. dissolutionDissolve the residue in water
  3. extractionextract with ethyl acetate
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo
  6. customPurify by silica gel chromatography

Sources & evidence

ORD record
ord-51273a50ac7b47d580626bcfb359b914
Source dataset
uspto-grants-1993_06
Patent number
US05217964

Reaction notes

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