HCID 19757881, compound → HCID 19757866, compound

HRID 1587549Notes

Reaction equation

HRID 1587549 reaction equation
[C:1]1([N:7]([S:39]([C:42]2[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=2)(=[O:41])=[O:40])[CH2:8][CH2:9][CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][CH2:14][N:15]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>Cl>[C:1]1([N:7]([S:39]([C:42]2[CH:43]=[CH:44][C:45]([CH3:48])=[CH:46][CH:47]=2)(=[O:41])=[O:40])[CH2:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][N:15]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:17])=[O:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 19757881HCID 19757881, compound

Product 1

HCID 19757866HCID 19757866, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dissolve 1,9-bis[(phenyl)]-1,9-bis[(4-methylphenyl)sulfonyl]-5-(t-butyloxycarbonyl)-1,5,9-triazanonane (691 mg, 1 mmol) in saturated methanolic hydrochloric acid (10 mL). Stir for several hours and evaporate the solvent in vacuo. Dissolve the residue in water and neutralize with saturated sodium hydrogen carbonate and extract with ethyl acetate. Dry (MgSO4) and evaporate the solvent in vacuo. Purify by silica gel chromatography to give the title compound.

Workup

  1. customevaporate the solvent in vacuo
  2. dissolutionDissolve the residue in water
  3. extractionextract with ethyl acetate
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo
  6. customPurify by silica gel chromatography

Sources & evidence

ORD record
ord-b3672ecb1d024fdd974e5bf0ec276113
Source dataset
uspto-grants-1993_06
Patent number
US05217964

Reaction notes

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