1-Iodopropane → HCID 14822401, compound

HRID 1587757Notes

Reaction equation

HRID 1587757 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:19][C@H:18]2[C@@H:8]([CH2:9][C:10]3[C:20]4[C:13](=[CH:14][CH:15]=[CH:16][C:17]2=4)[NH:12][C:11]=3[CH3:21])[N:7]([C:22]#N)[CH2:6]1)=[O:4].[CH2:24](I)[CH2:25]C>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:19][C@H:18]2[C@@H:8]([CH2:9][C:10]3[C:20]4[C:13](=[CH:14][CH:15]=[CH:16][C:17]2=4)[NH:12][C:11]=3[CH3:21])[N:7]([CH2:22][CH2:24][CH3:25])[CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 86746966HCID 86746966, compound

Product 1

HCID 14822401HCID 14822401, compoundYield 54%

Procedure

As described at the beginning, the noncrystalline compound can be prepared from 6-cyano-2-methyl-8beta-ergoline-carboxylic acid methyl ester by reduction and alkylation with n-propyliodide in a 54% yield.

Sources & evidence

ORD record
ord-eadc7697840f4427b4efd211445f2b5d
Source dataset
uspto-grants-1993_06
Patent number
US05219862

Reaction notes

Loading…