Water → 2-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol

A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g-see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added over 10 minutes, dropwise, to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0°. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was then added dropwise with caution followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2×50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as an oil, yield 3.3 g.

1. filtrationThe mixture was filtered
2. washthe inorganic salts washed with ethyl acetate (2×50 ml)
3. concentrationconcentrated in vacuo

ORD record

ord-e48a477736d14b1080af998b887838cf

Source dataset

uspto-grants-1993_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05219871