反应详情

A solution of 3-nitrobenzenesulfonamide (615 mg) in 10 ml of dry tetrahydrofuran was cooled to 0° C. and mixed with 0.34 ml of acetic anhydride and 166 mg of 4-N,N-dimethylaminopyridine. The reaction mixture was stirred for 30 minutes, quenched with 10% citric acid solution, and diluted with ethyl acetate. The reaction mixture was extracted with ethyl acetate. The organic extracts were washed with brine, dried, concentrated in vacuo to yield 946 mg of the title compound in pure form.

1. customquenched with 10% citric acid solution
2. additiondiluted with ethyl acetate
3. extractionThe reaction mixture was extracted with ethyl acetate
4. washThe organic extracts were washed with brine
5. customdried
6. concentrationconcentrated in vacuo