反应详情

Sodium hydride (50% in oil, 0.53 g) is suspended in ether (20 ml), cooled to 0°, then treated dropwise with a mixture of acetophenone 1.2 ml) and ethyl formate (0.90 ml). The reaction is stirred 1 hr at 0° then overnight at 22°. The precipitate is filtered and washed well with ether to give a solid. The solid is suspended in ethanol (10 ml), cooled to 0°, then treated dropwise with tosyl azide (0.97 g). The reaction is stirred for 3 hrs, concentrated, dissolved in 1N sodium hydroxide and extracted with ether. The ether is washed with water, dried with sodium sulfate and concentrated to give the title compound.

1. temperaturecooled to 0°
2. customovernight
3. customat 22°
4. filtrationThe precipitate is filtered
5. washwashed well with ether
6. customto give a solid
7. temperaturecooled to 0°
8. stirringThe reaction is stirred for 3 hrs
9. concentrationconcentrated
10. dissolutiondissolved in 1N sodium hydroxide
11. extractionextracted with ether
12. washThe ether is washed with water
13. dry with materialdried with sodium sulfate
14. concentrationconcentrated