反应详情

3.1 g of 6-[4-(2-amino-2-methylpropylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone obtained in Example 1, (3) and 2.2 g of 1-(3,4-dihydrocarbostyril-5-yloxy) -2,3-epoxypropane were dissolved in 30 ml of isopropyl alcohol and heated with stirring for 20 hours. After the end of the reaction, the reaction solution was concentrated under reduced pressure. The residue was separated by silica gel chromatography (chloroformmethanbol=10:1). Recrystallization from dichloromethane -isopropanol gave 2.4 g of 6-[4-[2-[3-(3,4-di hydrocarbostyril-5-yloxy)2-hydroxypropylamino]-2-methylpropylamino]phenyl]-4,5-dihydro-3(2H)-pyridazinone.

1. temperatureheated
2. customAfter the end of the reaction
3. concentrationthe reaction solution was concentrated under reduced pressure
4. customThe residue was separated by silica gel chromatography (chloroformmethanbol=10:1)
5. customRecrystallization from dichloromethane -isopropanol