反应详情

Next, the ethyl 12-(tert-butyldimethylsilyloxy)octadecanoate thus obtained was introduced into a 100-ml flask equipped with a stirrer and 20 ml of ethanol and 2.24 g (20 mmol) of a 50% aqueous solution of KOH were added thereto. The obtained mixture was stirred at room temperature for 4 hours. After the completion of the reaction, the reaction mixture thus obtained was neutralized with hydrochloric acid and extracted with chloroform. After removing the solvent under reduced pressure, 4.0 g of 12-(tert-butyldimethylsilyloxy)octadecanoic acid was obtained (yield: 96.4 %).

1. additionwas introduced into a 100-ml flask
2. customequipped with a stirrer
3. customAfter the completion of the reaction
4. customthe reaction mixture thus obtained
5. extractionextracted with chloroform
6. customAfter removing the solvent under reduced pressure