Hexanoic acid, 2-bromo-, methyl ester → HCID 13706743, compound

HRID 1588411Notes

Reaction equation

HRID 1588411 reaction equation
Br[CH:2]([CH2:7][CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH3:6])=[O:4].[F-:11].[K+]>C(N)(=O)C>[F:11][CH:2]([CH2:7][CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH3:6])=[O:4]

Participants

4

Reactant 2

HCID 95578Hexanoic acid, 2-bromo-, methyl esterHCID 522689Potassium Fluoride

Product 1

HCID 13706743HCID 13706743, compound

Reagents, catalysts & solvents 1

HCID 178AcetamideSolvent

Conditions

Temperature
105 °C

Procedure

Methyl 2-bromocaproate (40 g) was added to anhydrous potassium fluoride (23 g) in acetamide (23 g) kept at 105° C. The mixture was vigorously stirred at 105° C. for 6 hours. The crude product obtained after the conventional work-up was distilled. Yield; 20 g (71 %), b.p.; 66° C./20 mmHg

Workup

  1. customkept at 105° C

Sources & evidence

ORD record
ord-29a8566348004da5a9a02deef3027dfa
Source dataset
uspto-grants-1993_06
Patent number
US05221763

Reaction notes

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