1,4-Dichlorobenzene → HCID 19755403, compound

HRID 1588433Notes

Reaction equation

HRID 1588433 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]1[CH:12]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:11][CH2:10][CH2:9][C:8]2=1)C=C.[CH:24]1[C:29](Cl)=CC=C(Cl)[CH:25]=1>>[CH2:29]([C:6]1[C:5]([OH:4])=[CH:17][CH:16]=[C:15]2[C:7]=1[C:8]1[CH2:9][CH2:10][CH2:11][CH:12]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]=1[NH:14]2)[CH:24]=[CH2:25]

Participants

3

Reactant 2

HCID 46851,4-DichlorobenzeneHCID 19755390HCID 19755390, compound

Product 1

HCID 19755403HCID 19755403, compound

Procedure

The product of Step 3 (400 mg) is heated in dichlorobenzene at 210° C. for 10 hours. Evaporation of the solvent and chromatography of the residue over silica gel using EtOAc-hexane yields ethyl 5-allyl-6-hydroxy-1,2,3,4-tetrahydrocarbazol-1-ylacetate.

Workup

  1. customEvaporation of the solvent and chromatography of the residue over silica gel

Sources & evidence

ORD record
ord-6c100568967c43d38087f80889db7dc7
Source dataset
uspto-grants-1993_06
Patent number
US05221678

Reaction notes

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