Hydrofluoric Acid → HCID 131718000, compound

HRID 1588442Notes

Reaction equation

HRID 1588442 reaction equation
F.[O:2]([CH:10]([C:31]([F:36])([F:35])[CH2:32][CH2:33][CH3:34])[CH2:11][CH2:12][CH2:13][C@H:14]1[C@H:18]([CH3:19])[CH2:17][C:16](=[O:20])[C@@H:15]1[CH2:21]/[CH:22]=[CH:23]\[CH2:24][CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])[Si](C(C)(C)C)(C)C>C(#N)C>[OH:2][CH:10]([C:31]([F:35])([F:36])[CH2:32][CH2:33][CH3:34])[CH2:11][CH2:12][CH2:13][C@H:14]1[C@H:18]([CH3:19])[CH2:17][C:16](=[O:20])[C@@H:15]1[CH2:21]/[CH:22]=[CH:23]\[CH2:24][CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28]

Participants

4

Reactant 2

HCID 14917Hydrofluoric AcidHCID 131718001HCID 131718001, compound

Product 1

HCID 131718000HCID 131718000, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Hydrofluoric acid (1 ml) was added to a solution of the compound (30) (0.201 g) in acetonitrile (20 ml). The resultant mixture was stirred at room temperature for 1 hour. The crude product obtained after the usual work-up was subjected to silicagel column chromatography to give the alcohol (31).

Workup

  1. customThe crude product obtained after the usual work-up

Sources & evidence

ORD record
ord-bfa113902e8649d09b84875394ef4c53
Source dataset
uspto-grants-1993_06
Patent number
US05221799

Reaction notes

Loading…