HCID 131718002, compound → HCID 15200565, compound

HRID 1588444Notes

Reaction equation

HRID 1588444 reaction equation
[F:1][C:2]([F:34])([CH2:31][CH2:32][CH3:33])[C:3](=[O:30])[CH2:4][CH2:5][CH2:6][C@H:7]1[C@H:11]([O:12]C2CCCCO2)[CH2:10][C:9](=[O:19])[C@@H:8]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27]>C(O)(=O)C.C1COCC1.O>[F:1][C:2]([F:34])([CH2:31][CH2:32][CH3:33])[C:3](=[O:30])[CH2:4][CH2:5][CH2:6][C@H:7]1[C@H:11]([OH:12])[CH2:10][C:9](=[O:19])[C@@H:8]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27]

Participants

5

Reactant 1

HCID 131718002HCID 131718002, compound

Product 1

HCID 15200565HCID 15200565, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The diketone (34) (0.371 g) was dissolved in a mixed solvent of acetic acid, THF and water (1:3:1, 35 ml), and the resultant solution was stirred overnight. The crude product obtained after the usual work-up was chromatographed on a Rober column (ODS) to give the titled compound (35).

Workup

  1. customThe crude product obtained after the usual work-up
  2. customwas chromatographed on a Rober column (ODS)

Sources & evidence

ORD record
ord-0922c01e34dd445fb76602aff749e257
Source dataset
uspto-grants-1993_06
Patent number
US05221799

Reaction notes

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