Potassium Carbonate → HCID 131718003, compound

HRID 1588445Notes

Reaction equation

HRID 1588445 reaction equation
C(=O)([O-])[O-].[K+].[K+].[O:7]([CH:15]([C:50]([F:55])([F:54])[CH2:51][CH2:52][CH3:53])[CH2:16][CH2:17][CH2:18][C@H:19]1[C@H:23]([O:24]C(=O)C2C=CC=CC=2)[CH2:22][C@H:21]([O:33][CH:34]2[CH2:39][CH2:38][CH2:37][CH2:36][O:35]2)[C@@H:20]1[CH2:40]/[CH:41]=[CH:42]\[CH2:43][CH2:44][CH2:45][C:46]([O:48][CH3:49])=[O:47])[Si:8]([C:11]([CH3:14])([CH3:13])[CH3:12])([CH3:10])[CH3:9]>CO>[O:7]([CH:15]([C:50]([F:55])([F:54])[CH2:51][CH2:52][CH3:53])[CH2:16][CH2:17][CH2:18][C@H:19]1[C@H:23]([OH:24])[CH2:22][C@H:21]([O:33][CH:34]2[CH2:39][CH2:38][CH2:37][CH2:36][O:35]2)[C@@H:20]1[CH2:40]/[CH:41]=[CH:42]\[CH2:43][CH2:44][CH2:45][C:46]([O:48][CH3:49])=[O:47])[Si:8]([C:11]([CH3:12])([CH3:13])[CH3:14])([CH3:9])[CH3:10]

Participants

4

Reactant 2

HCID 11430Potassium Carbonate2×HCID 131718004HCID 131718004, compound

Product 1

HCID 131718003HCID 131718003, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Potassium carbonate (0.125 g) was added to a solution of the compound (39) (0.689 g) in methanol, and the resultant mixture was stirred at room temperature for 2 hours. An additional amount (1.75 g) of potassium carbonate was added thereto, and the mixture was left on standing overnight. The crude product obtained after the usual work-up was subjected to silicagel column chromatography to give the monoalcohol (40).

Workup

  1. waitthe mixture was left
  2. customThe crude product obtained after the usual work-up

Sources & evidence

ORD record
ord-21ee4b45249d4661ae43333ceda66bfb
Source dataset
uspto-grants-1993_06
Patent number
US05221799

Reaction notes

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