3-Thiazolidinepropionic acid, 4-oxo-2-thioxo- → HCID 85648613, compound

HRID 1588467Notes

Reaction equation

HRID 1588467 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[C:12]([CH2:15][CH2:16][N:17]1[C:21](=[O:22])[CH2:20][S:19][C:18]1=[S:23])(O)=[O:13]>O1CCCC1>[N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([O:1][C:12]([CH2:15][CH2:16][N:17]2[C:21](=[O:22])[CH2:20][S:19][C:18]2=[S:23])=[O:13])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 814923-Thiazolidinepropionic acid, 4-oxo-2-thioxo-HCID 178516385quinolin-4-ol

Product 1

HCID 85648613HCID 85648613, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Three g of 4-hydroxyquinoline and 2 g of 3-carboxyethylrhodanine were added to 200 ml of tetrahydrofuran. Two g of N,N-dicyclohexylcarbodiimide was added to the solution. The material was stirred at room temperature for 8 hours. The resulting insoluble matters were removed by filtration. One l of ethyl acetate was added to the filtrate. The resulting crystal was filtered off to obtain 2.2 g of 3-(4-quinolyloxycarbonylethyl)rhodanine.

Workup

  1. customThe resulting insoluble matters were removed by filtration
  2. additionOne l of ethyl acetate was added to the filtrate
  3. filtrationThe resulting crystal was filtered off

Sources & evidence

ORD record
ord-9553138cd79744f2bad130ea98af5611
Source dataset
uspto-grants-1993_06
Patent number
US05223389

Reaction notes

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