反应详情

A mixture of 2-amino-4-anilino-6-methylpyrimidine (1 g) (5 mM), potassium carbonate (0.4 g, 5.5 mM), crotyl bromide (0.61 ml) (5 mM) and acetone (25 ml) was heated at reflux for 20 hours. The solvent was then evaporated and the residue triturated with methylene chloride. The methylene chloride extracts were combined and the solvent removed by evaporation. The residual syrup was purified by flash chromatography using Merck 9835 silica (200 g) and eluting with 5% v/v methanol/methylene chloride. There thus was obtained 4-anilino-2-crotylamino-6-methylpyrimidine as a viscous oil (0.36 g) which was used without characterisation.

1. temperaturewas heated
2. temperatureat reflux for 20 hours
3. customThe solvent was then evaporated
4. customthe residue triturated with methylene chloride
5. customthe solvent removed by evaporation
6. customThe residual syrup was purified by flash chromatography
7. washeluting with 5% v/v methanol/methylene chloride