Phenethylamine → HCID 19734487, compound

HRID 1588572Notes

Reaction equation

HRID 1588572 reaction equation
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9][CH:8]=1)OC)#[N:2].[C:15]1([CH2:21][CH2:22][NH2:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(OCC)C>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9][CH:8]=1)=[N:23][CH2:22][CH2:21][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)#[N:2]

Participants

5

Reactant 3

HCID 1001PhenethylamineHCID 3283Diethyl EtherHCID 19734524HCID 19734524, compound

Product 1

HCID 19734487HCID 19734487, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methyl N-cyano-4-cyanobenzenecarboximidate (0.37 g, 2.0 mmol) was suspended in methanol (4 ml), and 2-phenylethylamine (0.25 g, 2.1 mmol) was added. The mixture was stirred at room temperature for 1 hour. After the reaction was completed, methanol (6 ml) and diethyl ether (10 ml) were added to the reaction solution, and deposited crystals were collected by filtration to give the title compound (0.51 g, 1.87 mmol, yield: 94%) as colorless crystals.

Workup

  1. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-6b48672119bd4a94a694cc2d0d3463f2
Source dataset
uspto-grants-1993_06
Patent number
US05223508

Reaction notes

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