HCID 19754056, compound → HCID 19754059, compound

HRID 1588576Notes

Reaction equation

HRID 1588576 reaction equation
[CH2:1]([C:5]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[S:34]([NH:37]C(C)(C)C)(=[O:36])=[O:35])=[CH:24][CH:23]=2)[C:8]2=[N:9][CH:10]=[C:11]([NH:13][C:14](=[O:19])[CH2:15][CH2:16][CH2:17][CH3:18])[CH:12]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]>FC(F)(F)C(O)=O>[CH2:1]([C:5]1[N:20]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[S:34]([NH2:37])(=[O:36])=[O:35])=[CH:26][CH:27]=2)[C:8]2=[N:9][CH:10]=[C:11]([NH:13][C:14](=[O:19])[CH2:15][CH2:16][CH2:17][CH3:18])[CH:12]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 19754056HCID 19754056, compound

Product 1

HCID 19754059HCID 19754059, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 2-butyl-3-[[2'-[[(1,1-dimethyl-ethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]methyl]-6-[(1-oxopentyl)amino]-3H-imidazo[4,5-b]pyridine (710 mg, 1.23 mmol) in trifluoroacetic acid (50 mL) was stirred at r. t. for 12 h. The mixture was concentrated, dissolved in EtOAc (40 mL) and washed with saturated aqueous Na2CO3. The organic extracts were dried (K2CO3) and concentrated to give the title compound as a solid.

Workup

  1. concentrationThe mixture was concentrated
  2. dissolutiondissolved in EtOAc (40 mL)
  3. washwashed with saturated aqueous Na2CO3
  4. dry with materialThe organic extracts were dried (K2CO3)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-3d9e734b238f4f248e8197cb497e398c
Source dataset
uspto-grants-1993_06
Patent number
US05223499

Reaction notes

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