N,2,2-Trimethylpropanamide → HCID 178484903, compound

HRID 1588589Notes

Reaction equation

HRID 1588589 reaction equation
[CH3:1][NH:2][C:3](=O)[C:4]([CH3:7])([CH3:6])[CH3:5].[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>C1C=CC=CC=1.P(Cl)(Cl)(Cl)=O>[CH3:1][NH:2][C:3](=[N:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:4]([CH3:7])([CH3:6])[CH3:5]

Participants

5

Reactant 2

HCID 138844N,2,2-TrimethylpropanamideHCID 4587952-(Piperidin-1-yl)aniline

Product 1

HCID 178484903HCID 178484903, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolvent2×HCID 24813Phosphorus oxychlorideSolvent

Procedure

A mixture of N-methylpivalamide (11.5 g) in benzene (120 ml) and phosphorus oxychloride (9.2 ml) was stirred at room temperature for 3 days. A solution of 1-(2-aminophenyl)piperidine (14 g) in benzene (80 ml) was added and the mixture heated at 65°-70° C. for four days to give N-methyl-N'-(2-piperidinophenyl)pivalamidine (m.p. 78° C.) which was recrystallised from hexane. The product was obtained as a 0.25 hydrate.

Workup

  1. temperaturethe mixture heated at 65°-70° C. for four days

Sources & evidence

ORD record
ord-094cdff8dbaa45e7b0689ad85aa419f9
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

Loading…