Ethanol → HCID 178484907, compound

HRID 1588653Notes

Reaction equation

HRID 1588653 reaction equation
I.CS[C:4](=[N:18][CH3:19])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:20][O:21][CH2:22][CH2:23][NH2:24].C(O)C.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>CO>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[CH3:19][NH:18][C:4]([NH:24][CH2:23][CH2:22][O:21][CH3:20])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

6

Reactant 4

HCID 702EthanolHCID 80182-MethoxyethylamineHCID 444972Fumaric AcidHCID 18952225HCID 18952225, compound

Product 1

HCID 178484907HCID 178484907, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (3.9 g prepared as described in Example 210), 2-methoxyethylamine (0.82 g) and ethanol (25 ml) was stored at ambient temperature for three months to yield an oil which was dissolved in methanol and treated with fumaric acid to give 1-methyl-2-(2-morpholinophenyl)-3-(2-methoxyethyl)guanidine monofumarate (m.p. 158°-160° C.) which was recrystallised rom a 1:2 mixture of methanol and ether.

Workup

  1. waitwas stored at ambient temperature for three months
  2. customto yield an oil which

Sources & evidence

ORD record
ord-68966713820449c2ab3ec395bd99c4c8
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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