Methyl iodide → 2-Methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide

HRID 1588658Notes

Reaction equation

HRID 1588658 reaction equation
[CH2:1]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[S:7])[CH2:2][CH2:3][CH3:4].[CH3:22][I:23]>CC(C)=O>[IH:23].[CH3:22][S:7][C:6](=[N:5][CH2:1][CH2:2][CH2:3][CH3:4])[NH:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 189522771-(n-Butyl)-3-(5-chloro-2-morpholinophenyl)thiourea

Product 1

HCID 189522972-Methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1-(n-butyl)-3-(5-chloro-2-morpholinophenyl)thiourea (2.6 g), methyl iodide (1.4 g) and acetone (20 ml) was heated under reflux for 3 hours to give 2-methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide (m.p. 130°-132° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours

Sources & evidence

ORD record
ord-94bf1645f4a1483889e491817ed7974e
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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