Potassium Hydroxide → HCID 18952118, compound

HRID 1588690Notes

Reaction equation

HRID 1588690 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([NH:8][C:9]([NH2:11])=S)[CH:7]=1.O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C.[OH-].[K+]>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([NH:8][C:9]#[N:11])[CH:7]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 18952303HCID 18952303, compound

Product 1

HCID 18952118HCID 18952118, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A mixture of 1-(5-fluoro-2-morpholinophenyl)thiourea (5.1 g) suspended in water (36.5 ml), lead acetate trihydrate (7.95 g) in water (36 ml) and potassium hydroxide (11.45 g) in water (32 ml) was heated under reflux for 25 minutes to give N-(5-fluoro-2-morpholinophenyl)cyanamide as a white solid (m.p. 168°-170° C.).

Workup

  1. temperatureunder reflux for 25 minutes

Sources & evidence

ORD record
ord-28fb1798bade4dcfb074dc2bef24dbe2
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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