Methanol → 3-Methoxy-3-oxo-2-phenylpropanoic acid

HRID 1588790Notes

Reaction equation

HRID 1588790 reaction equation
[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B(F)(F)F.[CH3:18]COCC.CO>>[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([O:10][CH3:18])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 8000Boron trifluoride etherateHCID 75791Phenylmalonic acid

Product 1

HCID 28177753-Methoxy-3-oxo-2-phenylpropanoic acid

Procedure

A mixture of phenylmalonic acid (3.6 g, 0.02 mol), boron trifluoride etherate (2.4 mL, 0.02 mol) and 0.8 mL of anhydrous methanol (0.02 mol) was refluxed and stirred for 24 hours. After cooling to room temperature, the reaction mixture was filtered and 20 mL of water was added.

Workup

  1. temperaturewas refluxed
  2. filtrationthe reaction mixture was filtered
  3. addition20 mL of water was added

Sources & evidence

ORD record
ord-edc591666f8e40be91565d0d7e4fb516
Source dataset
uspto-grants-1993_06
Patent number
US05223528

Reaction notes

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