4-Ethoxyphenol → HCID 19754876, compound

HRID 1588927Notes

Reaction equation

HRID 1588927 reaction equation
[CH:1]([N:4]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][C:9](Br)=[CH:8][CH:7]=1)([CH3:3])[CH3:2].[CH2:20]([O:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[CH3:21]>N1C(C)=CC(C)=CC=1C>[CH:14]1([N:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:13])[C:6]2[CH:11]=[CH:10][C:9]([O:29][C:26]3[CH:27]=[CH:28][C:23]([O:22][CH2:20][CH3:21])=[CH:24][CH:25]=3)=[CH:8][CH:7]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 121504-EthoxyphenolHCID 19754886HCID 19754886, compound

Product 1

HCID 19754876HCID 19754876, compound

Reagents, catalysts & solvents 1

HCID 79532,4,6-TrimethylpyridineSolvent

Procedure

The reaction and workup are carried out in the same manner as described for Example 1 using p-bromobenzoic acid N-isopropyl-N-cyclohexyl amide (1.75g, 5.40 mmol), 4-ethoxy phenol (796 mg, 5.76 mmol) and cuprous oxide (390 mg, 2.73 mmol) in collidine (15 ml). The crude product is chromatographed on silica gel using mixtures of ethyl acetate and hexane as eluents to give the title compound.

Workup

  1. customThe reaction and workup
  2. customThe crude product is chromatographed on silica gel using mixtures of ethyl acetate and hexane as eluents

Sources & evidence

ORD record
ord-5d09d660ffdc4e2e831eabcf8fc72ec3
Source dataset
uspto-grants-1993_06
Patent number
US05223539

Reaction notes

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