4-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide → 4-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine

HRID 1588973Notes

Reaction equation

HRID 1588973 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:11]([C:22]([NH2:24])=O)[CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:11]([CH2:22][NH2:24])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 149987544-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 149987714-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine

Procedure

In a manner similar to Preparation 2, react 4-(3-methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide (0.9 g, 27 mmol) with lithium aluminum hydride (2.1 g, 55 mmol) to give the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-a50557f6ef2c4d69b36e8b4588fcc57e
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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