Hydrochloric Acid → 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

HRID 1588980Notes

Reaction equation

HRID 1588980 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20](N)=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:23].[K+].Cl.O>C(O)CO>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20]([OH:21])=[O:23])[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 109900971-Benzyl-4-phenyl-piperazine-2-carboxamide

Product 1

HCID 149988012-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Conditions

Temperature
150 °C

Procedure

Suspend 4-phenyl-1-(phenylmethyl)-2-piperazinecarboxamide (14.5 g, 49 mmol) in ethylene glycol (400 mL) and add potassium hydroxide (27.5 g, 490 mmol). Heat this mixture to 150° C. for 18 h. After this time, remove the solvent in vacuo. Add 6M hydrochloric acid (81.5 mL, 0.49 mol) and water (300 mL) and filter the resultant solid to obtain the title compound.

Workup

  1. customAfter this time, remove the solvent in vacuo
  2. filtrationfilter the resultant solid

Sources & evidence

ORD record
ord-6a44282423354bc5be620a297419ab21
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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