N-[4-[[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl]amino]phenyl]methanesulfonamide, hydrochloride → N-[4-[[(1-Phenylpiperazin-2-yl)methyl]amino]phenyl]methanesulfonamide

HRID 1589037Notes

Reaction equation

HRID 1589037 reaction equation
Cl.[C:2]1([N:8]2[CH2:13][CH2:12][N:11](CC3C=CC=CC=3)[CH2:10][CH:9]2[CH2:21][NH:22][C:23]2[CH:28]=[CH:27][C:26]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:25][CH:24]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH3:3][C:2]#[N:8].[NH4+:8].[OH-:31].[C:2]1([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH2:21][NH:22][C:23]2[CH:28]=[CH:27][C:26]([NH:29][S:30]([CH3:33])(=[O:31])=[O:32])=[CH:25][CH:24]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 131718014N-[4-[[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl]amino]phenyl]methanesulfonamide, hydrochloride

Product 2

HCID 14998853N-[4-[[(1-Phenylpiperazin-2-yl)methyl]amino]phenyl]methanesulfonamideHCID 19098099CH3CN NH4OH

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a manner similar to Example 1, react N-[4-[[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl]amino]phenyl]methanesulfonamide, hydrochloride (2.92 g, 6.0 mmol) with H2 over 10% palladium on activated charcoal (0.29 g). Chromatograph the residue on silica with CH2CN/NH4OH (99/1) to obtain the title compound,

Sources & evidence

ORD record
ord-9436e68ff226412eb465144e8c7d7cc7
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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