反应详情

A solution of guanidine hydrochloride (0.20 g), ethyl 4-{[4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetoacetate (0.99 g), and 1,5-diazabicyclo[4.3.0]non-5-ene (0.30 g) in ethanol (50 ml) was stirred at room temperature for 5 days and then evaporated. The residue was dissolved in chloroform and washed with 2M hydrochloric acid, 10% aqueous sodium carbonate, and water, dried (MgSO4), and evaporated. The residual solid was recrystallised from ethyl acetate to give the title compound (0.23 g), m.p. 185°-187° C. Found: C,56.08; H,5.14; N,11.33. C23H25ClN4O6 requires C,56.50; H,5.15; N,11.46%.

1. customevaporated
2. dissolutionThe residue was dissolved in chloroform
3. washwashed with 2M hydrochloric acid, 10% aqueous sodium carbonate, and water
4. dry with materialdried (MgSO4)
5. customevaporated
6. customThe residual solid was recrystallised from ethyl acetate