Cyanamide → HCID 13365722, compound

Participants

Reaction Steps

3.92 g (0.02 mol) of 2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole hydrochloride and 0.95 g of cyanamide in 20 ml of n-amyl alcohol are heated to boiling for 2 hours. After distilling out the solvent, the residue is taken up in boiling ethanol, active charcoal is added, and, after filtration, the filtrate is evaporated in vacuo. After recrystallisation from isopropanol/ethyl acetate, 2.4 g of the hydrochloride of 2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole-1-carboximidamide are obtained. Melting point 233°-234° C.

Provenance & Evidence