Cyanamide → HCID 13365722, compound

HRID 1589171Notes

Reaction equation

HRID 1589171 reaction equation
Cl.[NH:2]1[N:6]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[CH:5]2[CH2:4][CH2:3]1.[N:14]#[C:15][NH2:16]>CCCCCO>[N:2]1([C:15](=[NH:14])[NH2:16])[N:6]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[CH:5]2[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 9864CyanamideHCID 13365721HCID 13365721, compound

Product 1

HCID 13365722HCID 13365722, compound

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Procedure

3.92 g (0.02 mol) of 2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole hydrochloride and 0.95 g of cyanamide in 20 ml of n-amyl alcohol are heated to boiling for 2 hours. After distilling out the solvent, the residue is taken up in boiling ethanol, active charcoal is added, and, after filtration, the filtrate is evaporated in vacuo. After recrystallisation from isopropanol/ethyl acetate, 2.4 g of the hydrochloride of 2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole-1-carboximidamide are obtained. Melting point 233°-234° C.

Workup

  1. distillationAfter distilling out the solvent
  2. additionis added
  3. filtrationafter filtration
  4. customthe filtrate is evaporated in vacuo
  5. customAfter recrystallisation from isopropanol/ethyl acetate, 2.4 g of the hydrochloride of 2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole-1-carboximidamide
  6. customare obtained

Sources & evidence

ORD record
ord-cd09c629903d43b4b3da9d3778657d85
Source dataset
uspto-grants-1986_02
Patent number
US04568688

Reaction notes

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