HCID 20248332, compound → N-[4-(imidazol-1-yl)butyl]phthalimide

HRID 1589195Notes

Reaction equation

HRID 1589195 reaction equation
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].Br.Br[CH2:15][CH2:16][CH2:17][CH2:18][N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>CN(C)C=O>[N:19]1([CH2:18][CH2:17][CH2:16][CH2:15][N:5]2[C:1](=[O:11])[C:2]3[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4]2=[O:6])[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

4

Reactant 2

HCID 20248332HCID 20248332, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 13290795N-[4-(imidazol-1-yl)butyl]phthalimide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 0.02 mole of potassium phthalimide, 0.01 mole of N-(4-bromobutyl)imidazole hydrobromide and 100 ml. of dimethyl formamide was gradually heated to 80° C. and held at this temperature for 3 hours. The solvent was removed in vacuo and the residue was purified by HPLC using ethyl acetate and a silica gel column.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by HPLC

Sources & evidence

ORD record
ord-043a502dada74e2081bd393ae1528957
Source dataset
uspto-grants-1986_02
Patent number
US04568687

Reaction notes

Loading…