Methylamine → HCID 178485214, compound
Reaction equation
[CH3:1][S:2]([N:5]=[C:6](SC)[S:7][CH3:8])(=[O:4])=[O:3].[CH3:11][NH2:12]>C(O)C>[CH3:11][NH:12][C:6](=[N:5][S:2]([CH3:1])(=[O:4])=[O:3])[S:7][CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 53 °C
Procedure
A mixture of N-methylsulphonyl-bis(methylthio)methanimine (188 g) and ethanol (760 ml) was stirred and warmed to 53° C. and the resulting solution was treated dropwise at 45° C. with a solution of methylamine in ethanol (33% w/w; 115 ml) during 2 hours. The solution was then stirred at room temperature for 7 hours and allowed to stand overnight. The solution was concentrated in vacuo to low volume and crystallised from cold ethanol, to give N-methyl-N'-methylsulphonyl-S-methylisothiourea (162 g), m.p. 88°-91° C.
Workup
- stirringThe solution was then stirred at room temperature for 7 hours
- concentrationThe solution was concentrated in vacuo to low volume
- customcrystallised from cold ethanol
Sources & evidence
- ORD record
- ord-ecdf31c405454b679f871671e12f6a6c
- Source dataset
- uspto-grants-1986_02
- Patent number
- US04568694
Reaction notes
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