HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 5-Dimethylaminomethyluracil Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Uracil | HCID 1174 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Dimethylaminomethyluracil Hydrochloride | HCID 12267435 | — |
Reaction Steps
Uracil (56.05 g, 0.50 mol) was refluxed with dimethylamine hydrochloride (81.55 g, 1.0 mol) and 37% aqueous formaldehyde (61 mL, 1.0 mol) in water (100 mL) for two days. The solvent was evaporated and the product triturated with methanol. After filtration and drying, the title compound was isolated (80.6 g, 78.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04568744 |
| Source dataset | uspto-grants-1986_02 |
| ORD ID | ord-07b90253f4d245ee83c65207305eb442 |
| Source note | uspto-grants-1986_02 |