Formaldehyde → 5-Dimethylaminomethyluracil Hydrochloride

HRID 1589245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589245
[NH:1]1[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[ClH:9].[CH3:10][NH:11][CH3:12].[CH2:13]=O>O>[ClH:9].[CH3:10][N:11]([CH2:13][C:7]1[C:5](=[O:6])[NH:4][C:2](=[O:3])[NH:1][CH:8]=1)[CH3:12]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 1174UracilHCID 10473Dimethylamine, hydrochloride

Produkt 1

HCID 122674355-Dimethylaminomethyluracil Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Uracil (56.05 g, 0.50 mol) was refluxed with dimethylamine hydrochloride (81.55 g, 1.0 mol) and 37% aqueous formaldehyde (61 mL, 1.0 mol) in water (100 mL) for two days. The solvent was evaporated and the product triturated with methanol. After filtration and drying, the title compound was isolated (80.6 g, 78.3%).

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe product triturated with methanol
  3. filtrationAfter filtration
  4. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-07b90253f4d245ee83c65207305eb442
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04568744

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